Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.74 |
| ▸ | RAB9A | P51151 | 12/20 | 0.74 |
| ▸ | PKM | P14618 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | MAOB | P27338 | 1/20 | 0.74 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.74 |
| ▸ | SCD | O00767 | 1/20 | 0.67 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235922 | 0.87 | RAB9A (0.57) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11708176 | 0.87 | NPC1 (0.56) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL3926899 | 0.86 | NPC1 (1.00) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11706324 | 0.85 | NPC1 (0.81) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11703736 | 0.84 | NPC1 (0.91) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11731227 | 0.84 | NPC1 (0.55) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11703862 | 0.83 | NPC1 (0.83) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11707899 | 0.81 | SCD (1.00) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL11811427 | 0.80 | NPC1 (0.60) | NPC1RAB9APKMSMN1; SMN2MAOB | |
| SCHEMBL22236216 | 0.80 | HDAC1 (0.53) | NPC1RAB9APKMSMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011236-A | N-(BENZIMIDAZOL-2-YL)ARYLCARBOXAMIDES AS ULTRAVIOLET (UV) LIGHT ABSORBERS | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |
| US-4009164-A | Novel 2-substituted-1,2,4-thiadiazole-[2,3-a]-benzimidazoles and process for their preparation | SYNTEX (U.S.A.) INC. (US) | 1977-02-22 | — | — | US | disclosed |
| US-3946031-A | FUNGICIDES | SYNTEX INC. (US) | 1976-03-23 | — | — | US | disclosed |