SCHEMBL11705121

SCHEMBL11705121

CC(=O)Oc1c(C)c(C)c(OC(C)=O)c(CCC(=O)c2ccccc2)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
MAPT P10636 2/20 0.41
LMNA P02545 1/20 0.41
NR4A2 P43354 1/20 0.41
KMT2A Q03164 4/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
ELANE P08246 1/20 0.41
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 2/20 0.38
GAA P10253 1/20 0.38
CYP2C19 P33261 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7188194 0.82 NPC1 (0.51) NPC1RAB9AL3MBTL1TDP1MAPT
SCHEMBL10383779 0.78 CA2 (0.35) L3MBTL1LMNAKMT2AALDH1A1MEN1
SCHEMBL11704397 0.74 IAPP (0.33) LMNA
SCHEMBL11766222 0.70 PTGER4 (0.43) NPC1TDP1MAPTKMT2AALDH1A1
SCHEMBL11766228 0.70 PTGER4 (0.43) NPC1TDP1MAPTKMT2AALDH1A1
SCHEMBL9049629 0.69 NPC1 (0.74) NPC1RAB9AL3MBTL1TDP1MAPT
SCHEMBL11785689 0.69 IMPDH2 (0.38) MAPTKMT2AMEN1HDAC3HDAC4
SCHEMBL11703549 0.69 MEN1 (0.34) MAPTKMT2AALDH1A1MEN1
Acetic Acid Phenyl Ester SCHEMBL30176020 0.68 NR4A2 (0.67) RAB9AL3MBTL1TDP1MAPTLMNA
SCHEMBL7188122 0.68 NPC1 (0.51) NPC1RAB9AL3MBTL1TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4026907-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-05-31 US disclosed
US-4018799-A INTERMEDIATES FOR TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-04-19 US disclosed
US-4003919-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-01-18 US disclosed
US-3947473-A (6-HYDROXY-CHROMAN-2-YL) CARBOXYLIC ACID DERIVATIVES HOFFMAN-LA ROCHE INC. (US) 1976-03-30 US disclosed