Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.70 |
| ▸ | WNT3A | P56704 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795459 | 0.91 | CTNNB1 (0.62) | CTNNB1WNT3ATSHRMAPTPAX8 | |
| SCHEMBL6085421 | 0.90 | CTNNB1 (0.56) | CTNNB1WNT3ATSHRMAPTALDH1A1 | |
| SCHEMBL10455919 | 0.87 | CTNNB1 (0.83) | CTNNB1WNT3ATSHRMAPTPAX8 | |
| SCHEMBL31314527 | 0.86 | MEN1 (0.70) | CTNNB1WNT3ATSHRMAPTMAPK1 | |
| SCHEMBL2848397 | 0.86 | MEN1 (0.70) | CTNNB1WNT3ATSHRMAPTMAPK1 | |
| SCHEMBL4266164 | 0.85 | MEN1 (0.57) | CTNNB1WNT3ATSHRMAPK1ALDH1A1 | |
| SCHEMBL2088969 | 0.84 | CTNNB1 (0.54) | CTNNB1WNT3ATSHRMAPTMAPK1 | |
| SCHEMBL15988664 | 0.83 | CTNNB1 (0.67) | CTNNB1WNT3ATSHRMAPTMAPK1 | |
| SCHEMBL15988936 | 0.83 | TSHR (0.73) | CTNNB1WNT3ATSHRMAPTMAPK1 | |
| SCHEMBL15969047 | 0.83 | CTNNB1 (1.00) | CTNNB1WNT3ATSHRMAPTPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011321-A | 6-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXYARYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-03-08 | — | — | US | disclosed |