SCHEMBL11705183

SCHEMBL11705183

O=C(Cc1ccc(C2CCCCC2)cc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HAO1 Q9UJM8 1/20 0.57
BCL2L1 Q07817 1/20 0.51
MCL1 Q07820 1/20 0.51
KMO O15229 1/20 0.50
SIGMAR1 Q99720 1/20 0.48
PLAU P00749 1/20 0.47
EPHX2 P34913 1/20 0.46
MAPT P10636 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
S1PR5 Q9H228 2/20 0.46
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
LMNA P02545 1/20 0.45
POLB P06746 1/20 0.45
HTT P42858 1/20 0.45
RORC P51449 1/20 0.45
SRD5A2 P31213 2/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11705201 0.94 HAO1 (0.61) HAO1BCL2L1MCL1KMOEPHX2
SCHEMBL3706067 0.89 MAPT (0.56) HAO1BCL2L1MCL1SIGMAR1PLAU
SCHEMBL16178628 0.89 HAO1 (0.53) HAO1BCL2L1MCL1KMOSIGMAR1
SCHEMBL6276699 0.82 HAO1 (0.55) HAO1BCL2L1MCL1MAPTALDH1A1
SCHEMBL11674678 0.82 HAO1 (0.53) HAO1BCL2L1MCL1KMOEPHX2
SCHEMBL2649112 0.82 HAO1 (0.53) HAO1BCL2L1MCL1KMOEPHX2
SCHEMBL7199268 0.79 MAPT (0.67) PLAUMAPTL3MBTL1S1PR5ALDH1A1
SCHEMBL11218828 0.78 KMO (0.57) HAO1KMOMAPTL3MBTL1ALDH1A1
SCHEMBL16178630 0.78 NPC1 (0.54) EPHX2MAPTL3MBTL1SRD5A2
SCHEMBL4049737 0.78 KMT2A (0.61) HAO1KMOMAPTALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4016214-A Preparation of ethynylbenzenes WILLIAM H. RORER, INC. (US) 1977-04-05 US disclosed
US-3952067-A Ethynylbenzenes WILLIAM H. RORER, INC. (US) 1976-04-20 US disclosed