Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16020436 | 0.81 | HPGD (0.49) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL11701235 | 0.76 | HPGDS (0.62) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL11370730 | 0.74 | HPGDS (0.55) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL12042444 | 0.74 | PTGS1 (0.64) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| Oxalic Acid SCHEMBL11706932 | 0.73 | PTGS1 (0.64) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| Oxalic Acid SCHEMBL11703550 | 0.71 | PTGS1 (0.61) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL6793430 | 0.70 | HPGDS (0.83) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL28807604 | 0.69 | HPGDS (0.65) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL11703751 | 0.68 | HPGDS (0.54) | HPGDSALDH1A1HPGDKDM4EPTGS1 | |
| SCHEMBL8439895 | 0.67 | HPGDS (0.78) | HPGDSALDH1A1HPGDKDM4EPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | claimed |