Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.62 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705299 | 1.00 | PTGS2 (0.62) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL11707022 | 0.88 | PTGS1 (0.77) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL11707009 | 0.88 | PTGS1 (0.77) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL7704968 | 0.85 | PTGS2 (0.71) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL5313395 | 0.85 | PTGS2 (0.71) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL14010207 | 0.84 | MEN1 (0.60) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL11703218 | 0.84 | HDAC1 (0.50) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL10025981 | 0.83 | AKR1B1 (0.69) | PTGS2PTGS1SLC22A6AKR1C3AKR1C2 | |
| SCHEMBL1217681 | 0.83 | AKR1B1 (0.69) | PTGS2PTGS1SLC22A6AKR1C3AKR1C2 | |
| SCHEMBL4679446 | 0.83 | AKR1B1 (0.69) | PTGS2PTGS1SLC22A6AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | claimed |
| US-4064132-A | ANTIINFLAMMATORY AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-12-20 | — | — | US | disclosed |
| US-4060528-A | ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-11-29 | — | — | US | disclosed |
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |