Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705395 | 1.00 | HPGD (0.64) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| SCHEMBL11727367 | 0.82 | GAA (0.44) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| SCHEMBL11727375 | 0.82 | GAA (0.44) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| (S)-Suprofen SCHEMBL5102821 | 0.78 | PTGS2 (1.00) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| (R)-Suprofen SCHEMBL1122667 | 0.78 | PTGS2 (1.00) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| SCHEMBL12286991 | 0.78 | HPGD (0.83) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| Suprofen SCHEMBL23792 | 0.78 | PTGS2 (1.00) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| SCHEMBL3805719 | 0.77 | HPGD (0.76) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| SCHEMBL11706983 | 0.77 | HPGD (0.76) | HPGDALDH1A1PTGS1PTGS2CYP2C9 | |
| SCHEMBL11703369 | 0.77 | HPGD (0.76) | HPGDALDH1A1PTGS1PTGS2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4064132-A | ANTIINFLAMMATORY AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-12-20 | — | — | US | disclosed |
| US-4060528-A | ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-11-29 | — | — | US | disclosed |
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |