Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Suprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 7/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
| ▸ | HPGDS | O60760 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (S)-Suprofen SCHEMBL5102821 | 1.00 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| (R)-Suprofen SCHEMBL1122667 | 1.00 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL9621599 | 0.98 | PTGS2 (0.97) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL3971318 | 0.97 | PTGS2 (0.94) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL3262801 | 0.97 | PTGS2 (0.94) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| SCHEMBL12286991 | 0.91 | HPGD (0.83) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL11706680 | 0.91 | PTGS2 (0.82) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| SCHEMBL14213389 | 0.88 | HPGD (0.78) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL3971317 | 0.86 | PTGS1 (0.74) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| SCHEMBL11703369 | 0.86 | HPGD (0.76) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 34390 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130928-A1 | COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN | ASCENTAWITS PHARMACEUTICALS LTD (CN) | 2026-05-14 | — | — | US | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-20260048096-A1 | METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS | STEALTH BIOTHERAPEUTICS INC. (US) | 2026-02-19 | — | — | US | claimed |
| US-20260000741-A1 | METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE | ACERAGEN INC (US) | 2026-01-01 | — | — | US | claimed |
| US-20250381195-A1 | Methods of Treating Diabetic Macular Edema | UNM RAINFOREST INNOVATIONS (US) | 2025-12-18 | — | — | US | claimed |
| EP-3699174-B1 | COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME | ILAB (KR) | 2025-11-12 | — | — | EP | claimed |
| EP-4628080-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Jeil Pharmaceutical Co., Ltd. (KR) | 2025-10-08 | — | — | EP | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| EP-0072462-A2 | Pharmaceutical preparations | Toko Yakuhin Industry Co., Ltd. (JP) | 1983-02-23 | — | — | EP | claimed |
| EP-0018732-B1 | AN ALPHA-METHYL-4(2'-THIENYL-CARBONYL)PHENYL ACETIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND ITS PHARMACEUTICAL USE | LABORATORIOS CUSI, S.A. (ES) | 1983-01-12 | — | — | EP | claimed |
| US-4367176-A | Esters of arylpropionic acids endowed with an anti-inflammatory activity and related pharmaceutical compositions | AUSONIA FARMACEUTICI S.R.L. (IT) | 1983-01-04 | — | — | US | claimed |
| EP-0013110-B1 | ANALGESIC COMPOSITION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1982-09-29 | — | — | EP | claimed |
| US-4347373-A | Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole | TURCONI FRANCO | 1982-08-31 | — | — | US | claimed |
| US-4294852-A | WATER, AN ALIPHATIC ALCOHOL AND AN ORGANIC ACID TO ADJUST THE PH OF THE VEHICLE | JOHNSON & JOHNSON (US) | 1981-10-13 | — | — | US | claimed |
| EP-0036684-A1 | Derivatives of 4-methyl-5-(2-aminoethyl)-thiomethyl-imidazole having therapeutic activity | Turconi, Franco (IT) | 1981-09-30 | — | — | EP | claimed |
| EP-0014440-A1 | Ketal derivatives and the use thereof as intermediate products | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-08-20 | — | — | EP | claimed |
| US-4185100-A | CORTICOSTEROID AND A HYDROTROPIC ACID DERIVATIVE, ENZYME INHIBITORS | JOHNSON & JOHNSON (US) | 1980-01-22 | — | — | US | claimed |
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | claimed |