Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668982 | 0.87 | HPGD (0.53) | POLBALDH1A1L3MBTL1TSHR | |
| SCHEMBL10695452 | 0.81 | TDP1 (0.45) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL11706074 | 0.80 | CA2 (0.51) | HSP90AA1HSP90AB1KMT2AALDH1A1LMNA | |
| SCHEMBL2239062 | 0.80 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1KMT2AMEN1MAPT | |
| SCHEMBL11633970 | 0.79 | KMT2A (0.40) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL11344938 | 0.79 | CA1 (0.54) | CA2CA12CA1CA7CA9 | |
| SCHEMBL9263357 | 0.78 | KMT2A (0.60) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL6810549 | 0.78 | L3MBTL1 (0.57) | POLBMAPTALDH1A1L3MBTL1TSHR | |
| SCHEMBL9373867 | 0.77 | MEN1 (0.48) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL9471937 | 0.77 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011321-A | 6-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXYARYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-03-08 | — | — | US | disclosed |