Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.70 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14220449 | 0.92 | NT5E (0.68) | NT5ENOX1PDGFRBMEN1KMT2A | |
| SCHEMBL1170563 | 0.87 | NT5E (0.74) | NT5ENOX1PDGFRBMEN1KMT2A | |
| SCHEMBL15093219 | 0.83 | NT5E (0.80) | NT5ENOX1PDGFRBMEN1KMT2A | |
| SCHEMBL12561674 | 0.82 | NT5E (1.00) | NT5ENOX1MEN1KMT2AMAPT | |
| SCHEMBL15093318 | 0.82 | NT5E (0.94) | NT5ENOX1MEN1KMT2AMAPT | |
| SCHEMBL6468783 | 0.80 | NT5E (0.80) | NT5EMEN1KMT2AMAPTMAPK14 | |
| SCHEMBL11054293 | 0.80 | NOX1 (0.72) | NOX1MEN1KMT2AMAPTHPGD | |
| SCHEMBL5571856 | 0.80 | NT5E (0.74) | NT5ENOX1PDGFRBMEN1KMT2A | |
| SCHEMBL12561653 | 0.78 | NT5E (0.85) | NT5EPDGFRBMEN1KMT2AMAPT | |
| SCHEMBL17366627 | 0.78 | NT5E (0.85) | NT5ENOX1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | claimed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | claimed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | claimed |
| EP-1531674-A2 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | Lorus Therapeutics Inc. (CA) | 2005-05-25 | — | — | EP | claimed |
| WO-2004016086-A2 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2004-02-26 | — | — | WO | claimed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2011-06-23 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| EP-1531674-A2 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | Lorus Therapeutics Inc. (CA) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004016086-A2 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | NT5E 161/4885NOX1 140/4885PDGFRB 4644/4885 |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | NT5E 161/4885NOX1 140/4885PDGFRB 4644/4885 |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | IDO2, ERG28, IL4 | NT5E 161/4885NOX1 140/4885PDGFRB 4644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.