Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11800308 | 0.86 | HCRTR1 (0.54) | HCRTR1ABCB1MAPTL3MBTL1LMNA | |
| SCHEMBL7460882 | 0.85 | HDAC8 (0.64) | L3MBTL1LMNAHDAC8HDAC1KMT2A | |
| SCHEMBL28779453 | 0.85 | HCRTR1 (0.58) | HCRTR1ABCB1MAPTL3MBTL1LMNA | |
| SCHEMBL11703134 | 0.83 | MEN1 (0.53) | ABCB1MAPTL3MBTL1LMNAHDAC8 | |
| SCHEMBL3029800 | 0.81 | HCRTR1 (0.62) | HCRTR1ABCB1MAPTL3MBTL1LMNA | |
| SCHEMBL8569591 | 0.81 | HDAC8 (0.67) | L3MBTL1LMNAHDAC8HDAC1KMT2A | |
| SCHEMBL1448831 | 0.80 | HCRTR1 (0.60) | HCRTR1ABCB1MAPTL3MBTL1LMNA | |
| SCHEMBL11706328 | 0.78 | HTT (0.40) | MAPTL3MBTL1LMNAHDAC8HDAC1 | |
| SCHEMBL5051477 | 0.78 | HCRTR1 (0.58) | HCRTR1MAPTL3MBTL1LMNAMAPK1 | |
| SCHEMBL30454895 | 0.78 | HCRTR1 (0.58) | HCRTR1MAPTL3MBTL1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4025558-A | SPIRO(CYCLOHEXANE-1,1*(2'H)-NAPHTHALENE); BENZOSPIRAN DERIVATIVES; CNS DEPRESSANTS, LOWERS BLOOD PRESSURE | THE UPJOHN COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-4010201-A | AMINOBENZOSPIRANS, CENTRAL NERVOUS SYSTEM DEPRESSANT, HYPOTENSIVE | THE UPJOHN COMPANY (US) | 1977-03-01 | — | — | US | disclosed |
| US-3932425-A | CNS DEPRESSANT, BLOOD PRESSURE LOWERING | THE UPJOHN COMPANY (US) | 1976-01-13 | — | — | US | disclosed |