Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11576431 | 0.89 | HPGD (0.46) | HTR1AHTR3ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11763884 | 0.85 | SLC6A4 (0.44) | HTR1AHTR3ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11761224 | 0.85 | HTR1A (0.51) | HTR1AHTR3ASLC6A4PKMHPGD | |
| SCHEMBL11702988 | 0.84 | HTR1A (0.49) | HTR1AHTR3ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL956490 | 0.83 | HTR1A (0.51) | HTR1AHTR3ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11711077 | 0.79 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2HPGDSMN1; SMN2 | |
| SCHEMBL11704531 | 0.79 | AGBL2 (0.46) | SLC6A4SLC6A3SLC6A2HPGDKMT2A | |
| SCHEMBL11709008 | 0.79 | HTR1A (0.45) | HTR1AHTR3ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11705979 | 0.79 | CYP2C9 (0.54) | HTR1AHTR3AHPGDSMN1; SMN2TDP1 | |
| SCHEMBL11759836 | 0.78 | IDO1 (0.53) | HTR1AHTR3ASLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4006145-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-01 | — | — | US | disclosed |
| US-4006144-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-01 | — | — | US | disclosed |