Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11490665 | 0.88 | LMNA (0.53) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL13243338 | 0.85 | ALOX15 (0.51) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL11703589 | 0.83 | ALOX15 (0.50) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL11705521 | 0.82 | HPGD (0.56) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL11702544 | 0.82 | ALOX15 (0.49) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL11705531 | 0.82 | HPGD (0.56) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL256810 | 0.75 | ALOX15 (0.57) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL10136508 | 0.75 | LMNA (0.62) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| SCHEMBL11704482 | 0.74 | ALOX15 (0.56) | LMNAALOX15ALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL10588359 | 0.74 | LMNA (0.60) | LMNAALOX15ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4064132-A | ANTIINFLAMMATORY AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-12-20 | — | — | US | disclosed |
| US-4060528-A | ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-11-29 | — | — | US | disclosed |
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |