Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | CTH | P32929 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL28098324 | 1.00 | GABRR1 (0.57) | GABRR1TP53SLC7A5GSRGLRA1 | |
| Ethylenediamine SCHEMBL26086247 | 1.00 | GABRR1 (0.57) | GABRR1TP53SLC7A5GSRGLRA1 | |
| Ethylenediamine SCHEMBL27951423 | 0.97 | GABRR1 (0.55) | GABRR1TP53SLC7A5GSRGLRA1 | |
| Monoethanolamine SCHEMBL28219640 | 0.88 | GABRR1 (0.52) | GABRR1TP53SLC7A5GSRGLRA1 | |
| SCHEMBL11703090 | 0.85 | LMNA (0.52) | GABRR1GSRRNPEP | |
| Lactic Acid SCHEMBL27979213 | 0.84 | TP53 (0.69) | GABRR1TP53SLC7A5GSRRNPEP | |
| Alanine SCHEMBL20740651 | 0.84 | GABRR1 (0.55) | GABRR1TP53SLC7A5GSRSLC1A3 | |
| Lactic Acid SCHEMBL31326881 | 0.84 | TP53 (0.69) | GABRR1TP53SLC7A5GSRRNPEP | |
| Methylamine SCHEMBL1871435 | 0.82 | — | — | |
| Hydrazine SCHEMBL15610528 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4026831-A | ADHESIVES, PAINT RESINS, ELECTROSTATIC INHIBITORS, RUST INHIBITORS | MIYOSHI YUSHI KABUSHIKI KAISHA (JA) | 1977-05-31 | — | — | US | disclosed |