SCHEMBL11708552

SCHEMBL11708552

COC1(c2ccccc2)CCc2c(C)c(O)c(C)c(C)c2O1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.49
PTGS2 P35354 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
TSHR P16473 1/20 0.49
BCHE P06276 6/20 0.41
ACHE P22303 6/20 0.41
MAPT P10636 2/20 0.40
LMNA P02545 2/20 0.40
MEN1 O00255 1/20 0.40
GSTP1 P09211 1/20 0.40
TTPA P49638 1/20 0.40
KMT2A Q03164 1/20 0.40
USP2 O75604 1/20 0.40
THRB P10828 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
NR1I2 O75469 2/20 0.40
ALOX5 P09917 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29066385 0.86 PTGS2 (0.39) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL29066397 0.86 PTGS2 (0.39) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL29066379 0.86 PTGS2 (0.39) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL29066376 0.80 CYP19A1 (0.36) CYP3A4TSHRMAPTLMNAALOX5
SCHEMBL11705977 0.80 PTGS1 (0.52) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL9313974 0.73 CYP3A4 (0.49) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL7327753 0.73 CYP3A4 (0.57) PTGS1PTGS2CYP1A2CYP3A4TSHR
SCHEMBL29066396 0.73 PTGS2 (0.34) PTGS2CYP3A4MAPTMEN1KMT2A
SCHEMBL29066377 0.73 PTGS2 (0.34) PTGS2CYP3A4MAPTMEN1KMT2A
SCHEMBL29066413 0.73 PTGS2 (0.34) PTGS2CYP3A4MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4026907-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-05-31 US disclosed
US-4018799-A INTERMEDIATES FOR TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-04-19 US disclosed
US-4003919-A INTERMEDIATES FOR ALPHA-TOCOPHEROL HOFFMANN-LA ROCHE INC. (US) 1977-01-18 US disclosed
US-3947473-A (6-HYDROXY-CHROMAN-2-YL) CARBOXYLIC ACID DERIVATIVES HOFFMAN-LA ROCHE INC. (US) 1976-03-30 US disclosed