Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 8/20 | 0.97 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.63 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.63 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.63 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.63 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 11/20 | 0.97 |
| ▸ | HTR2A | P28223 | 3/20 | 0.70 |
| ▸ | HTR7 | P34969 | 2/20 | 0.70 |
| ▸ | DRD1 | P21728 | 2/20 | 0.68 |
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25173335 | 0.98 | DRD2 (1.00) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL29723260 | 0.98 | DRD2 (1.00) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL31029854 | 0.98 | DRD2 (1.00) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL59765 | 0.98 | DRD2 (1.00) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL31079473 | 0.98 | DRD2 (1.00) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL28132334 | 0.97 | DRD2 (0.97) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL28132381 | 0.97 | DRD2 (0.97) | DRD2HTR1AHTR2AHTR7DRD1 | |
| Hydrochloric Acid SCHEMBL11707353 | 0.97 | DRD2 (0.97) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL28809991 | 0.97 | DRD2 (0.97) | DRD2HTR1AHTR2AHTR7DRD1 | |
| SCHEMBL27927648 | 0.97 | DRD2 (0.97) | DRD2HTR1AHTR2AHTR7DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4013664-A | PSCHORR CYCLIZATION | RESEARCH CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |