Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649708 | 0.98 | HAO1 (0.61) | HAO1GSK3BHDAC1HDAC8HDAC3 | |
| SCHEMBL4875484 | 0.84 | MAPT (0.67) | HAO1GSK3BHPGDNPC1RAB9A | |
| SCHEMBL11707718 | 0.81 | HAO1 (0.68) | HAO1GSK3BHDAC1HDAC8HPGD | |
| SCHEMBL751516 | 0.80 | HPGD (0.74) | HAO1GSK3BHDAC1HDAC8HDAC3 | |
| SCHEMBL1305020 | 0.80 | GSK3B (0.70) | HAO1GSK3BHDAC1HDAC8HDAC3 | |
| SCHEMBL11709368 | 0.79 | PLOD2 (0.55) | HPGDNPC1RAB9AMAPTCES1 | |
| SCHEMBL10645841 | 0.79 | NPC1 (0.63) | GSK3BHDAC1HDAC6HPGDNPC1 | |
| SCHEMBL11705647 | 0.79 | ERCC5 (0.67) | GSK3BNPC1RAB9AMAPTCES1 | |
| SCHEMBL28079414 | 0.79 | GSK3B (0.48) | HAO1GSK3BHDAC1HDAC8HDAC3 | |
| SCHEMBL28037967 | 0.79 | HAO1 (0.89) | HAO1GSK3BHDAC1HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4058558-A | 2-METHYLENE-4-OXO-4(4'-ORTHO-CHLOROPHENYLPHENYL)BUTYRIC ACID | PIERRE FABRE S.A. (FR) | 1977-11-15 | — | — | US | disclosed |
| US-4008323-A | Method of reducing cholesterol using certain aromatic keto acids | PIERRE FABRE S.A. (FR) | 1977-02-15 | — | — | US | disclosed |