Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11713031 | 0.89 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA4CHRNA2PPARD | |
| SCHEMBL11460365 | 0.78 | SLC6A9 (0.52) | PPARDNQO2MTNR1AMTNR1B | |
| SCHEMBL15464723 | 0.74 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA4CHRNA2PPARD | |
| SCHEMBL11712965 | 0.73 | CHRNB2 (0.43) | CHRNB2CHRNB4CHRNA4CHRNA2PPARD | |
| SCHEMBL22712769 | 0.69 | PPARD (0.52) | CHRNB2CHRNB4CHRNA4CHRNA2PPARD | |
| SCHEMBL11831136 | 0.69 | FFAR1 (0.38) | PPARDLMNAPPARAFFAR4 | |
| SCHEMBL16763017 | 0.69 | CHRNB2 (0.51) | CHRNB2CHRNB4CHRNA4CHRNA2KMT2A | |
| SCHEMBL28348568 | 0.68 | CYP11B1 (0.42) | CHRNB2CHRNB4CHRNA4CHRNA2PPARD | |
| SCHEMBL11709686 | 0.67 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA4CHRNA2KMT2A | |
| SCHEMBL11709694 | 0.67 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA4CHRNA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4053476-A | 7-AZA-6-ALKOXY-1-TETRALONES | G. D. SEARLE & CO. (US) | 1977-10-11 | — | — | US | disclosed |
| US-3991061-A | Azanaphthaleneacetic acid derivatives | G. D. SEARLE & CO. (US) | 1976-11-09 | — | — | US | disclosed |