⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20926910 | 0.91 | SIGMAR1 (0.31) | — | |
| SCHEMBL11720710 | 0.81 | SIGMAR1 (0.37) | — | |
| SCHEMBL11719181 | 0.79 | SIGMAR1 (0.46) | — | |
| SCHEMBL1603764 | 0.73 | HSD11B1 (0.41) | — | |
| SCHEMBL23735320 | 0.72 | — | — | |
| SCHEMBL21216739 | 0.72 | — | — | |
| SCHEMBL15623958 | 0.72 | — | — | |
| SCHEMBL21216738 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL7527143 | 0.71 | HSD11B1 (0.39) | — | |
| SCHEMBL20858594 | 0.70 | GABRR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4064135-A | Certain thiazole-5-carboxamide compounds | SYNTEX (U.S.A.) INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064258-A | Thiazole cardiovascular agents | SYNTEX (U.S.A.) INC. (US) | 1977-12-20 | — | — | US | disclosed |