Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Meclofenoxate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 1/20 | 0.92 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenoxate SCHEMBL147339 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| Meclofenoxate SCHEMBL28363047 | 0.96 | CYP1A2 (0.97) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| Meclofenoxate SCHEMBL218322 | 0.96 | BLM (1.00) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| SCHEMBL12742257 | 0.84 | SMN1; SMN2 (0.97) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| SCHEMBL31122986 | 0.82 | SMN1; SMN2 (0.73) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| SCHEMBL28252143 | 0.80 | CYP1A2 (0.70) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| Meclofenoxate SCHEMBL28278857 | 0.80 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| SCHEMBL6598625 | 0.79 | HRH3 (0.69) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| SCHEMBL30836944 | 0.79 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C19BLMPMP22 | |
| SCHEMBL21384542 | 0.79 | CYP1A2 (0.68) | CYP1A2CYP3A4CYP2C19BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214382-A | Meclofenoxate hydrochloride compound and pharmaceutical composition thereof | SICHUAN HUIDA PHARMACEUTICAL CO LTD | 2013-07-24 | — | — | CN | claimed |
| CN-110015966-B | Preparation method of meclofenoxate hydrochloride | 广东先强药业有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-113332271-A | Application of meclofenoxate hydrochloride in preparation of medicine for preventing or treating Parkinson's disease | 中山大学孙逸仙纪念医院 | 2021-09-03 | — | — | CN | disclosed |
| CN-113332271-A | Application of meclofenoxate hydrochloride in preparation of medicine for preventing or treating Parkinson's disease | 中山大学孙逸仙纪念医院 | 2021-09-03 | — | — | CN | disclosed |
| CN-106769710-B | Quickly judge the method for meclofenoxate hydrochloride powder-injection quality condition | 北京市药品检验所 | 2019-05-21 | — | — | CN | disclosed |
| CN-106769710-A | The quick method for judging meclofenoxate hydrochloride powder-injection quality condition | 北京市药品检验所 | 2017-05-31 | — | — | CN | disclosed |
| CN-104072382-B | The synthesis technique of meclofenoxate hydrochloride crude product | JIANGSU HI-STONE PHARMACEUTICAL CO., LTD. (CN) | 2015-10-28 | — | — | CN | disclosed |
| CN-104651085-A | Detergent for lead-polluted building wastes | YANTAI SHUNLONG CHEMICAL ENGINEERING CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-104072382-A | Synthetic process of crude meclofenoxate hydrochloride | JIANGSU HI STONE PHARMACEUTICAL CO LTD | 2014-10-01 | — | — | CN | disclosed |
| CN-104058979-A | Purification process of meclofenoxate hydrochloride | JIANGSU HI STONE PHARMACEUTICAL CO LTD | 2014-09-24 | — | — | CN | disclosed |
| CN-101229149-B | Meclofenoxate hydrochloride stomach-floating sustained release capsule and preparing method thereof | SHANGHAI PHARMACEUTICAL INDUSTRY CO LTD | 2010-12-08 | — | — | CN | disclosed |
| CN-101756952-A | Pharmaceutical composition of meclofenoxate hydrochloride and polyethylene glycol and preparation method thereof | SIHUAN RES INST OF CARDIOVASCU | 2010-06-30 | — | — | CN | disclosed |
| CN-101278924-B | Meclofenoxate hydrochloride microcapsule and method for preparing injection thereof | HAINAN BAINA MEDICAL DEV CO LTD | 2010-06-09 | — | — | CN | disclosed |
| CN-100584383-C | Pharmaceutical composition with Meclofenoxate hydrochloride capable of preventing hydrolysis | GUANGZHOU YOUYI MEDICAL TECHNOLOGY DEV CO LTD | 2010-01-27 | — | — | CN | disclosed |
| CN-101278924-A | Meclofenoxate hydrochloride microcapsule and method for preparing injection thereof | HAINAN BAINA MEDICAL DEV CO LT (CN) | 2008-10-08 | — | — | CN | disclosed |
| CN-101229149-A | Meclofenoxate hydrochloride stomach-floating sustained release capsule and preparing method thereof | SHANGHAI PHARMACEUTICAL INDUST (CN) | 2008-07-30 | — | — | CN | disclosed |
| US-20070244143-A1 | MODULATION OF NEUROGENESIS BY NOOTROPIC AGENTS | BRAINCELLS, INC (US) | 2007-10-18 | — | — | US | disclosed |
| CN-100998585-A | Injection containing meclofenoxate hydrochloride and its preparing method | ZHENDI MEDICINE CONSULTATION C (CN) | 2007-07-18 | — | — | CN | disclosed |
| CN-1951501-A | Pharmaceutical composition with Meclofenoxate hydrochloride capable of preventing hydrolysis | GUANGZHOU YOUYI MEDICAL TECHNO (CN) | 2007-04-25 | — | — | CN | disclosed |
| CN-1742717-A | Liquid medicine containing lucidril and preparing method | QIAO JIE (CN) | 2006-03-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244143-A1 | MODULATION OF NEUROGENESIS BY NOOTROPIC AGENTS | GAP43, BDNF, DCX | CYP1A2 4792/4885CYP3A4 4880/4885CYP2C19 4866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.