Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amfenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amfenac SCHEMBL11467023 | 0.98 | ABCB11 (0.58) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL11727116 | 0.97 | ABCB11 (0.59) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL9644552 | 0.97 | — | — | |
| Amfenac SCHEMBL29603368 | 0.97 | — | — | |
| Amfenac SCHEMBL9747739 | 0.97 | ABCB11 (0.59) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL11730572 | 0.97 | ABCB11 (0.59) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL2254 | 0.95 | — | — | |
| Amfenac SCHEMBL11459150 | 0.95 | ABCB11 (0.58) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL11460876 | 0.95 | ABCB11 (0.58) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Amfenac SCHEMBL3500793 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4045576-A | ANTI-INFLAMMATORY METHODS USING 2-AMINO-3-(5- AND 6-)BENZOYLPHENYLACETIC ACIDS, ESTERS AND METAL SALTS THEREOF AND THE COMPOUNDS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1977-08-30 | — | — | US | claimed |