Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Amfenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amfenac SCHEMBL3500793 | 1.00 | — | — | |
| Amfenac SCHEMBL8347441 | 0.99 | — | — | |
| Amfenac SCHEMBL29603368 | 0.98 | — | — | |
| Amfenac SCHEMBL9644552 | 0.98 | — | — | |
| Amfenac SCHEMBL11459150 | 0.97 | ABCB11 (0.58) | — | |
| Amfenac SCHEMBL11467023 | 0.97 | ABCB11 (0.58) | — | |
| Amfenac SCHEMBL11460876 | 0.97 | ABCB11 (0.58) | — | |
| Amfenac SCHEMBL11726336 | 0.95 | ABCB11 (0.59) | — | |
| Amfenac SCHEMBL9747739 | 0.95 | ABCB11 (0.59) | — | |
| Amfenac SCHEMBL11730572 | 0.95 | ABCB11 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5621 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-12617762-B2 | Carboxy derivatives with antiinflamatory properties | SITRYX THERAPEUTICS LIMITED (GB) | 2026-05-05 | — | — | US | claimed |
| US-20260085061-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2026-03-26 | — | — | US | claimed |
| EP-4081511-B3 | CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES | SITRYX THERAPEUTICS LTD (GB) | 2026-03-04 | — | — | EP | claimed |
| US-12545750-B2 | Method for the diimide hydrogenation of emulsified unsaturated polymers | PARKER DANE K (US) | 2026-02-10 | — | — | US | claimed |
| EP-4634167-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | Sitryx Therapeutics Limited (GB) | 2025-10-22 | — | — | EP | claimed |
| EP-4612132-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2025-09-10 | — | — | EP | claimed |
| EP-4543875-A1 | OXADIAZOLE DERIVATIVES, PREPARATION PROCESS THEREOF AND THEIR USE IN TREATING INFLAMMATORY DISEASES | Sitryx Therapeutics Limited (GB) | 2025-04-30 | — | — | EP | claimed |
| CN-119874621-A | Pharmaceutical composition containing pyrazole ether compound and application thereof | 上海晓明检测技术服务有限公司 | 2025-04-25 | — | — | CN | claimed |
| EP-0435362-B1 | COMPOSITION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY AGENT AND EFFECTIVELY NON-ANTIBACTERIAL TETRACYCLINE | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1993-04-21 | — | — | EP | claimed |
| EP-0435362-A1 | Composition comprising non-steroidal anti-inflammatory agent and effectively non-antibacterial tetracycline | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1991-07-03 | — | — | EP | claimed |
| EP-0233910-B1 | PLANT PROTECTING COMPOSITION | INNOFINANCE Altalános Innovácios Pénzintézet (HU) | 1990-09-19 | — | — | EP | claimed |
| EP-0225005-B1 | ANTI-INFLAMMATORY ANALGESIC ADHESIVE PREPARATION | NITTO DENKO CORPORATION (JP) | 1990-03-14 | — | — | EP | claimed |
| US-4740374-A | Anti-inflammatory analgesic adhesive preparation | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1988-04-26 | — | — | US | claimed |
| EP-0233910-A1 | PLANT PROTECTING COMPOSITION. | INNOFINANCE ALTALANOS INNOVACI (HU) | 1987-09-02 | — | — | EP | claimed |
| EP-0225005-A1 | Anti-inflammatory analgesic adhesive preparation | NITTO DENKO CORPORATION (JP) | 1987-06-10 | — | — | EP | claimed |
| WO-1987000400-A1 | PLANT PROTECTING COMPOSITION | INNOFINANCE ÁLTALÁNOS INNOVÁCIÓS PÉNZINTÉZET (HU) | 1987-01-29 | — | — | WO | claimed |
| US-4221716-A | Intermediate and process for the preparation of 7-acylindolin-2-ones | A. H. ROBINS COMPANY, INC. (US) | 1980-09-09 | — | — | US | claimed |
| US-4126635-A | ANTICHOLESTEROL, BLOOD PLATELET AGGREGATION INHIBITION | A. H. ROBINS COMPANY, INCORPORATED (US) | 1978-11-21 | — | — | US | claimed |