Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL30701111 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL36149 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9561748 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3275086 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5473889 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5987710 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL16671164 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL36150 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5473892 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4608211 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10666 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122081122-A | Bacillus composite microbial agent and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026107252-A1 | METHODS AND SYSTEMS FOR CONTINUOUS OPERATION OF DIRECT RECYCLING OF LITHIUM ION BATTERY WASTE | LI INDUSTRIES, INC. (US) | 2026-05-21 | — | — | WO | claimed |
| CN-122064976-A | On-line efficiency running state detection method and system based on industrial stream data | 中南大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122056342-A | Roxburgh rose lactobacillus solid beverage and application thereof in preparing foods, health products or medicines for reducing hyperlipidemia, preventing colonitis and resisting oxidization | 贵州极海果蔬饮品工程技术有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122067720-A | APG settlement method and system based on portal disease type grouping | 南京非线数联科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122038222-A | Lactobacillus gasseri CCFM1530 for promoting bifidobacterium bifidum growth and freeze-drying resistance through metabolism | 江南大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122031279-A | Hair dyeing composition based on hydrogen peroxide and preparation method thereof | 四川中科兴业高新材料有限公司 | 2026-05-15 | — | — | CN | claimed |
| WO-2026099462-A1 | METHOD FOR PURIFYING RADIUM FROM BARIUM AND IMPURITIES IN AQUEOUS SOLUTION | ORANO (FR) | 2026-05-15 | — | — | WO | claimed |
| CN-121412453-B | Feature interaction method and device based on dynamic diagram constraint | 北京天源迪科网络科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4493286-B1 | A SOLID CLEANSING COMPOSITION | UNILEVER IP HOLDINGS B V (NL) | 2026-05-06 | — | — | EP | claimed |
| US-4761211-A | Method of improving the electrical characteristics of a thin film | THE GENERAL ELECTRIC COMPANY, P.L.C. (GB) | 1988-08-02 | — | — | US | claimed |
| US-4549903-A | Herbicidal compositions of acifluorfen or salts thereof and citrates | ROHM AND HAAS COMPANY (US) | 1985-10-29 | — | — | US | claimed |
| US-4544462-A | DISSOLVING BY INTRODUCTION OF ELECTRONS | HITACHI, LTD. (JP) | 1985-10-01 | — | — | US | claimed |
| US-4371573-A | Electroless deposition of nickel coatings and depositing baths therefor | SIEMENS AKTIENGESELLSCHAFT (DE) | 1983-02-01 | — | — | US | claimed |
| EP-0011368-B1 | NICOTINE TRANSFER PROCESS | LOEW'S THEATRES, INCORPORATED (US) | 1982-08-04 | — | — | EP | claimed |
| US-4215706-A | Nicotine transfer process | LOEW'S THEATRES, INC. (US) | 1980-08-05 | — | — | US | claimed |
| EP-0011368-A1 | Nicotine transfer process | LOEW'S THEATRES, INCORPORATED (US) | 1980-05-28 | — | — | EP | claimed |
| WO-1980000780-A1 | NICOTINE TRANSFER PROCESS | LOEWS THEATRES INC (US) | 1980-05-01 | — | — | WO | claimed |
| US-4113579-A | ANODIZING AN ALUMINUM FOIL | SPRAGUE ELECTRIC COMPANY (US) | 1978-09-12 | — | — | US | claimed |
| US-4030907-A | COMPLEX OF COPPER SALT WITH AN ALKANOLAMINE AND AMMONIUM COMPOUND | THOMPSON-HAYWARD CHEMICAL CO. (US) | 1977-06-21 | — | — | US | claimed |