Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.61 |
| ▸ | DRD1 | P21728 | 2/20 | 0.61 |
| ▸ | DRD5 | P21918 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11734250 | 0.91 | HTR2A (0.65) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11739126 | 0.89 | HTR2A (0.60) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11739185 | 0.89 | HTR2A (0.60) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11733974 | 0.89 | HTR2A (0.60) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11735738 | 0.86 | HTR2A (0.56) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11734599 | 0.82 | HTR2A (0.57) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL11739130 | 0.81 | HTR2A (0.56) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL5335494 | 0.81 | HTR2A (0.68) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11734812 | 0.80 | HTR2A (0.60) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL11616766 | 0.79 | ADRA2B (0.60) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031221-A | ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | claimed |
| US-4031221-A | ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |