Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11739126 | 0.88 | HTR2A (0.60) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL11734250 | 0.88 | HTR2A (0.65) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL11733974 | 0.86 | HTR2A (0.60) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL11735694 | 0.86 | DRD2 (0.61) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL11739185 | 0.86 | HTR2A (0.60) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL11737683 | 0.84 | HTR1D (0.48) | HTR2AHTR1A | |
| SCHEMBL11617255 | 0.81 | ADRA2B (0.60) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL11734599 | 0.80 | HTR2A (0.57) | HTR2ADRD2DRD3ADRA2AADRA2B | |
| SCHEMBL3444662 | 0.79 | HTR2A (0.52) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL11736973 | 0.79 | HTR2A (0.51) | HTR2ADRD2DRD3ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031221-A | ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |