Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.56 |
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SCN1A | P35498 | 3/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | THPO | P40225 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11735085 | 0.98 | HTR2A (0.55) | HTR2AHRH1CHRM2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL11734245 | 0.93 | HTR2A (0.53) | HTR2AHRH1CHRM2SLC6A2SLC6A4 | |
| SCHEMBL12300267 | 0.78 | HTR2A (0.64) | HTR2AHRH1CHRM2SLC6A2SLC6A4 | |
| SCHEMBL23138901 | 0.78 | HTR2A (0.64) | HTR2AHRH1CHRM2SLC6A2SLC6A4 | |
| SCHEMBL7302725 | 0.77 | HRH1 (0.39) | HTR2AHRH1TSHRCYP2D6SIGMAR1 | |
| SCHEMBL11569538 | 0.77 | HTR2A (0.65) | HTR2AHRH1CHRM2SLC6A2SLC6A4 | |
| SCHEMBL28256789 | 0.77 | HDAC3 (0.38) | HTR2AHRH1TSHRCYP2D6LMNA | |
| SCHEMBL28258221 | 0.77 | HDAC3 (0.38) | HTR2AHRH1TSHRCYP2D6LMNA | |
| SCHEMBL11188504 | 0.75 | SIGMAR1 (0.61) | HTR2AHRH1CHRM2SLC6A2SLC6A4 | |
| SCHEMBL11583390 | 0.75 | HTR2A (0.61) | HTR2AHRH1CHRM2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031245-A | TETRABENAZINE, ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1977-06-21 | — | — | US | claimed |
| US-3978129-A | TETRABENAZINE ANTAGONISM | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-08-31 | — | — | US | claimed |