Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11739805 | 0.85 | POLB (0.60) | KDM4ELMNAALDH1A1MEN1MAPT | |
| SCHEMBL11735457 | 0.84 | GABRA1 (0.47) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL25286563 | 0.83 | ALDH1A1 (0.64) | NPC1SMN1; SMN2NR4A2KDM4ETSHR | |
| SCHEMBL31579492 | 0.81 | NPC1 (0.50) | NPC1SMN1; SMN2HSD11B1NR4A2KDM4E | |
| SCHEMBL31579248 | 0.81 | NPC1 (0.50) | NPC1SMN1; SMN2HSD11B1NR4A2KDM4E | |
| SCHEMBL1559372 | 0.81 | NR4A2 (0.57) | NPC1SMN1; SMN2NR4A2KDM4ETSHR | |
| SCHEMBL1559006 | 0.80 | ALDH1A1 (0.65) | NPC1SMN1; SMN2NR4A2KDM4ETSHR | |
| SCHEMBL1558915 | 0.78 | KDM4E (0.57) | NPC1SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL11738453 | 0.77 | POLB (0.60) | NPC1KDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL11738779 | 0.76 | POLB (0.65) | KDM4ELMNAALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031221-A | ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |