SCHEMBL11736622

SCHEMBL11736622

COc1cccc2cc(C(C)C=O)ccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
HDAC4 P56524 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
NQO1 P15559 1/20 0.40
CYP2D6 P10635 1/20 0.39
CYP2A6 P11509 2/20 0.36
EGFR P00533 1/20 0.36
PDGFRB P09619 1/20 0.36
KDR P35968 1/20 0.36
LMNA P02545 1/20 0.36
RECQL P46063 1/20 0.36
KMT2A Q03164 1/20 0.35
FLT3 P36888 1/20 0.35
TLR2 O60603 1/20 0.35
ERN1 O75460 1/20 0.35
TLR1 Q15399 1/20 0.35
TLR6 Q9Y2C9 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11742912 0.88 ALDH1A1 (0.43) ALDH1A1KDM4EHPGDHSD17B10HDAC4
SCHEMBL11739039 0.84 DRD1 (0.38) CYP2D6AKR1B1MAPTL3MBTL1
SCHEMBL487736 0.82 HDAC4 (0.54) ALDH1A1KDM4EHPGDHSD17B10HDAC4
SCHEMBL11745462 0.81 PTGS2 (0.40) ALDH1A1KDM4EHPGDHSD17B10CYP2D6
SCHEMBL11746263 0.80 CYP1A2 (0.50) ALDH1A1HPGDHSD17B10CYP2D6CYP2A6
SCHEMBL3682240 0.79 SLC6A4 (0.47) ALDH1A1KMT2AERN1
SCHEMBL11740891 0.79 RXFP1 (0.36) ALDH1A1LMNAERN1MAPT
SCHEMBL11744099 0.79 CYP19A1 (0.44) ALDH1A1KDM4ELMNASMN1; SMN2CA1
SCHEMBL11744481 0.79 ALDH1A1 (0.35) ALDH1A1LMNAERN1CA1CA2
SCHEMBL27851959 0.79 ALDH1A1 (0.50) ALDH1A1KDM4EHPGDHSD17B10HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4045485-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ANTIPRURITIC ACTIVITY SYNTEX CORPORATION (US) 1977-08-30 US disclosed
US-3960936-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SKIN DISORDERS SYNTEX CORPORATION (PM) 1976-06-01 US disclosed
US-3947472-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC SYNTEX CORPORATION (PM) 1976-03-30 US disclosed
US-3935273-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC SYNTEX CORPORATION (US) 1976-01-27 US disclosed