SCHEMBL11739714

SCHEMBL11739714

CC=CC(=O)OCc1cccc(Cl)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 4/20 0.74
MMP1 P03956 1/20 0.50
MMP2 P08253 1/20 0.50
MMP9 P14780 1/20 0.50
MMP12 P39900 1/20 0.50
MAOA P21397 3/20 0.49
MAOB P27338 3/20 0.49
CYP3A4 P08684 2/20 0.47
IDO1 P14902 2/20 0.47
AGXT P21549 2/20 0.47
ALDH1A1 P00352 2/20 0.47
HTT P42858 1/20 0.47
HPGD P15428 1/20 0.47
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
EGFR P00533 1/20 0.47
JAK3 P52333 1/20 0.47
BTK Q06187 1/20 0.47
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11739701 1.00 HCAR2 (0.74) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL28592782 0.83 HCAR2 (0.51) HCAR2MMP2MMP9MMP12MAOA
SCHEMBL1592472 0.81 HCAR2 (0.68) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL14936905 0.81 HCAR2 (0.49) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL14936903 0.81 HCAR2 (0.49) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL28167053 0.81 MMP1 (0.53) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL28073168 0.81 MRGPRX4 (0.52) HCAR2EGFRJAK3BTK
SCHEMBL1070423 0.80 HCAR2 (0.71) HCAR2ALDH1A1EGFRJAK3BTK
SCHEMBL1070426 0.80 HCAR2 (0.71) HCAR2ALDH1A1EGFRJAK3BTK
SCHEMBL29883597 0.79 HCAR2 (0.62) HCAR2MMP1MMP2MMP9MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4044141-A CORONARY DILATING, SPASMOLYTIC, HYPOTENSIVE AGENTS BAYER AKTIENGESELLSCHAFT (DT) 1977-08-23 US disclosed