Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.53 |
| ▸ | RXRB | P28702 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410519 | 0.93 | MRGPRX4 (0.58) | MRGPRX4HPGDRXRARXRBSMN1; SMN2 | |
| SCHEMBL16584995 | 0.91 | MRGPRX4 (0.58) | MRGPRX4HPGDRXRARXRBSMN1; SMN2 | |
| SCHEMBL4403626 | 0.88 | SMN1; SMN2 (0.61) | MRGPRX4HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9574663 | 0.87 | MRGPRX4 (0.60) | MRGPRX4HPGDRXRARXRBSMN1; SMN2 | |
| SCHEMBL3231604 | 0.86 | MRGPRX4 (0.63) | MRGPRX4HPGDRXRARXRBSMN1; SMN2 | |
| SCHEMBL13440181 | 0.86 | FFAR4 (0.58) | MRGPRX4HPGDRXRARXRBSMN1; SMN2 | |
| SCHEMBL1561028 | 0.85 | EGFR (0.59) | HPGDSMN1; SMN2NPC1RAB9APPIA | |
| SCHEMBL4279981 | 0.85 | HSD17B10 (0.61) | MRGPRX4HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3178525 | 0.85 | HPGD (0.53) | MRGPRX4HPGDRXRARXRBSMN1; SMN2 | |
| SCHEMBL6508891 | 0.84 | LMNA (0.56) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4046909-A | Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-06 | — | — | US | disclosed |
| US-3998958-A | Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants | MCNEIL LABORATORIES, INCORPORATED (US) | 1976-12-21 | — | — | US | disclosed |