Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27867069 | 0.81 | KDM4C (0.46) | KDM4CKDM4EMEN1KDM6BKDM4A | |
| SCHEMBL11735065 | 0.79 | KDM4C (0.53) | KDM4CKDM4EMEN1KDM6BKDM4A | |
| Hydrochloric Acid SCHEMBL27341310 | 0.78 | KDM4C (0.51) | KDM4CKDM4EMEN1KDM6BKDM4A | |
| SCHEMBL11740499 | 0.76 | DPP4 (0.44) | KDM4CKDM4EMEN1KDM6BKDM4A | |
| SCHEMBL2223329 | 0.75 | NR4A1 (0.60) | KDM4CKDM4EMEN1KDM6BKDM4A | |
| SCHEMBL31522172 | 0.75 | NR4A1 (0.60) | KDM4CKDM4EMEN1KDM6BKDM4A | |
| SCHEMBL11476815 | 0.74 | IMPDH2 (0.35) | KDM4EALDH1A1MAPTHIPK2IMPDH2 | |
| SCHEMBL1193526 | 0.74 | WDR5 (0.66) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL11478088 | 0.74 | EP300 (0.44) | KDM4EHIPK2IMPDH2TNFCLK1 | |
| SCHEMBL30771576 | 0.74 | NR4A1 (0.58) | KDM4CKDM4EMEN1KDM6BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4062961-A | SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES | SMITHKLINE CORPORATION (US) | 1977-12-13 | — | — | US | disclosed |
| US-3988339-A | 7 OR 8-SUBSTITUTED 1,2,3,4-TETRAHYDRO-ISOQUINOLINE | SMITHKLINE CORPORATION (US) | 1976-10-26 | — | — | US | disclosed |