SCHEMBL11741237

SCHEMBL11741237

CC(=O)c1ccc2ccc(CC=O)cc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.56
KMT2A Q03164 3/20 0.46
MAPT P10636 3/20 0.45
HPGD P15428 2/20 0.45
ALDH1A1 P00352 2/20 0.45
HTT P42858 1/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
KDM4E B2RXH2 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
PKM P14618 1/20 0.39
GRIN2D O15399 1/20 0.38
GRIN2A Q12879 1/20 0.38
GRIN2B Q13224 1/20 0.38
GRIN2C Q14957 1/20 0.38
HSD17B10 Q99714 1/20 0.38
POLB P06746 1/20 0.37
ACHE P22303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10458014 0.82 CYP2A6 (0.59) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL1759076 0.82 CYP2A6 (0.44) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL11627138 0.81 PTGS1 (0.47) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL599006 0.81 CYP2A6 (0.79) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL29451111 0.81 CYP2A6 (0.79) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL1260786 0.79 KMT2A (0.64) KMT2AMAPTHPGDALDH1A1HTT
SCHEMBL10306521 0.78 KMT2A (0.63) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL23332977 0.77 CYP2A6 (0.52) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL6803029 0.77 CYP2A6 (0.53) CYP2A6KMT2AMAPTHPGDALDH1A1
SCHEMBL12253688 0.77 MAOB (0.50) KMT2AALDH1A1NPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4045485-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ANTIPRURITIC ACTIVITY SYNTEX CORPORATION (US) 1977-08-30 US disclosed
US-3960936-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SKIN DISORDERS SYNTEX CORPORATION (PM) 1976-06-01 US disclosed
US-3947472-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC SYNTEX CORPORATION (PM) 1976-03-30 US disclosed
US-3935273-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC SYNTEX CORPORATION (US) 1976-01-27 US disclosed