Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11741909 | 1.00 | MAPT (0.48) | MAPTLMNAALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL11742215 | 0.83 | SLC6A3 (0.50) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11742211 | 0.83 | SLC6A3 (0.50) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11740142 | 0.81 | GRM5 (0.67) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11740147 | 0.81 | GRM5 (0.67) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11737469 | 0.80 | MEN1 (0.49) | MAPTSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL11737472 | 0.80 | MEN1 (0.49) | MAPTSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL11737555 | 0.80 | GRM5 (0.62) | MAPTALDH1A1SMN1; SMN2L3MBTL1GRM5 | |
| SCHEMBL11737561 | 0.80 | GRM5 (0.62) | MAPTALDH1A1SMN1; SMN2L3MBTL1GRM5 | |
| SCHEMBL8326098 | 0.80 | L3MBTL1 (0.52) | MAPTALDH1A1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4046909-A | Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-06 | — | — | US | disclosed |
| US-3998958-A | Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants | MCNEIL LABORATORIES, INCORPORATED (US) | 1976-12-21 | — | — | US | disclosed |