Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11738746 | 0.85 | SIGMAR1 (0.42) | SIGMAR1SLC6A2SLC6A4ALDH1A1POLB | |
| Bromide SCHEMBL11733211 | 0.84 | SIGMAR1 (0.41) | SIGMAR1SLC6A2SLC6A4AKT1ALDH1A1 | |
| SCHEMBL11781822 | 0.81 | OPRD1 (0.44) | HTR2ASIGMAR1DRD2SLC6A2HTR2C | |
| SCHEMBL11730973 | 0.75 | SIGMAR1 (0.45) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL11781458 | 0.72 | OPRD1 (0.46) | HTR2ASIGMAR1DRD2SLC6A2HTR2C | |
| SCHEMBL3917884 | 0.65 | SIGMAR1 (0.42) | HTR2ASIGMAR1 | |
| SCHEMBL5271760 | 0.65 | — | — | |
| SCHEMBL17202972 | 0.64 | HTR2A (0.43) | HTR2ASIGMAR1DRD2SLC6A2HTR2C | |
| SCHEMBL29705809 | 0.64 | OPRD1 (0.50) | SIGMAR1DRD2 | |
| SCHEMBL4363631 | 0.64 | OPRD1 (0.50) | SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031224-A | 1,3-Dihydro-heteroarylspiro (isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |