Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773685 | 0.98 | LMNA (0.50) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL10570188 | 0.86 | TSHR (0.52) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL2773681 | 0.84 | MAPT (0.52) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL9316272 | 0.83 | LMNA (0.51) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL9316270 | 0.81 | LMNA (0.53) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL15227043 | 0.81 | NPC1 (0.49) | POLBTDP1MAPTKDM4ENPC1 | |
| SCHEMBL11744807 | 0.81 | LMNA (0.49) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL11037946 | 0.81 | LMNA (0.53) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL27755237 | 0.78 | LMNA (0.54) | LMNAPOLBTDP1MAPTMAPK1 | |
| SCHEMBL10878397 | 0.77 | POLB (0.57) | LMNAPOLBTDP1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4017615-A | ESPECIALLY USEFUL FOR ANTIINFLAMMATORY TOPICAL CORTICOIDS | SYNTEX CORPORATION (PM) | 1977-04-12 | — | — | US | disclosed |
| US-3962275-A | ANTIGONADOTROPIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-06-08 | — | — | US | disclosed |