SCHEMBL11746277

SCHEMBL11746277

Cc1ccc2sc3nncn3c2c1C

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 1/20 0.67
TNKS2 Q9H2K2 18/20 0.58
PARP2 Q9UGN5 17/20 0.58
PARP15 Q460N3 17/20 0.58
PARP10 Q53GL7 15/20 0.58
PARP14 Q460N5 2/20 0.50
TNKS O95271 1/20 0.43
PARP1 P09874 1/20 0.43
PARP11 Q9NR21 1/20 0.43
PARP4 Q9UKK3 1/20 0.43
PARP3 Q9Y6F1 1/20 0.43
GRM5 P41594 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tricyclazole SCHEMBL14721539 0.80 BRPF1 (1.00) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL11746637 0.71 PARP10 (0.37) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL25324694 0.71 TNKS2 (0.78) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL25324686 0.71 TNKS2 (1.00) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL25324482 0.70 TNKS2 (1.00) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL11744684 0.70 BRPF1 (0.66) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL11745019 0.70 BRPF1 (0.66) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL25324487 0.67 PARP2 (1.00) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL25324791 0.64 TNKS2 (0.78) BRPF1TNKS2PARP2PARP15PARP10
SCHEMBL25326183 0.64 TNKS2 (1.00) BRPF1TNKS2PARP2PARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4064261-A TRIAZOLOBENOXAZOLE, TRIAZOLOBENZOTHIAZOLE COMPOUNDS ELI LILLY AND COMPANY (US) 1977-12-20 US disclosed