Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6574366 | 0.87 | MAPT (0.71) | MAPTLMNAKDM4EALDH1A1POLB | |
| Iodide SCHEMBL3860161 | 0.87 | MAPT (0.61) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL6517662 | 0.85 | INSR (0.44) | MAPTLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL10589290 | 0.82 | MAPT (0.57) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL16195477 | 0.81 | MAPT (0.60) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL7997704 | 0.81 | MAPT (0.54) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL8009677 | 0.79 | MAPT (0.61) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL2030271 | 0.79 | MAPT (0.54) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL8775058 | 0.78 | MAPT (0.50) | MAPTLMNAKDM4EALDH1A1POLB | |
| SCHEMBL6822938 | 0.75 | MAPT (0.50) | MAPTLMNAKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE29168-E | HEAT SENSITIVE, ANTIHALATION LAYER | EASTMAN KODAK COMPANY (US) | 1977-04-05 | — | — | US | disclosed |