Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675183 | 0.87 | INSR (0.53) | INSRACHEHSD17B10ALDH1A1MAPT | |
| SCHEMBL11748071 | 0.85 | MAPT (0.53) | ACHEHSD17B10ALDH1A1MAPTCYP1A2 | |
| SCHEMBL11666197 | 0.82 | CYP1A2 (0.41) | INSRALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL316391 | 0.81 | MAPT (0.41) | HSD17B10ALDH1A1MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL5476170 | 0.81 | ACHE (0.41) | INSRACHEHSD17B10ALDH1A1MAPT | |
| SCHEMBL611706 | 0.79 | MAPT (0.40) | INSRALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL9199430 | 0.79 | MAPT (0.53) | INSRALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL316151 | 0.79 | ALDH1A1 (0.57) | HSD17B10ALDH1A1MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL8390923 | 0.78 | INSR (0.80) | INSRMAPTHTTKMT2ARAB9A | |
| SCHEMBL8390924 | 0.78 | INSR (0.80) | INSRMAPTHTTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-6361919-B1 | PHOTOSENSITIVE MATERIAL | KONICA CORPORATION (JP) | 2002-03-26 | — | — | US | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| EP-1011015-A1 | Silver halide photographic light sensitive material and hydrazine compound employed in it | KONICA CORPORATION (JP) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |
| EP-0754966-A1 | Silver halide light-sensitive photographic material and processing method thereof | KONICA CORPORATION (JP) | 1997-01-22 | — | — | EP | disclosed |
| US-4892812-A | GRAPHIC ARTS, ROOM-LIGHT, UNSENSITIZED, MERCAPTOBENZOIC ACID | MITSUBISHI PAPER MILLS, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |