Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754079 | 0.95 | MAPT (0.57) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11756967 | 0.95 | MAPT (0.57) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11748896 | 0.94 | KMT2A (0.71) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11753885 | 0.94 | KMT2A (0.71) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2395876 | 0.83 | RAB9A (0.49) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL10909889 | 0.82 | MAPT (0.62) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11756873 | 0.81 | MAPT (0.54) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11749316 | 0.81 | MAPT (0.54) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL12491432 | 0.81 | MAPT (0.61) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL3886944 | 0.81 | MAPT (0.89) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | disclosed |