Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196328 | 0.73 | HPGD (0.44) | SMN1; SMN2DHFRRXFP1ADORA2AHPGD | |
| SCHEMBL1329958 | 0.70 | HTT (0.46) | SMN1; SMN2MEN1KMT2ADHFRRXFP1 | |
| SCHEMBL14549434 | 0.68 | DHFR (0.43) | SMN1; SMN2MEN1KMT2ADHFRRXFP1 | |
| SCHEMBL11233643 | 0.68 | PDE7A (0.44) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1328569 | 0.68 | DHFR (0.47) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3791972 | 0.68 | DHFR (0.44) | SMN1; SMN2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL3791257 | 0.68 | MAPT (0.48) | SMN1; SMN2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL10976051 | 0.67 | CHRNA7 (0.42) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3063111 | 0.67 | LMNA (0.59) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4596087 | 0.65 | DYRK1A (0.41) | CYP3A4KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4002761-A | ANTHELMINTIC AGENTS, FUNGICIDAL AGENTS | SMITHKLINE CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |
| US-4000285-A | ANTHELMINTICS | SMITHKLINE CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |
| US-3961063-A | ANTHELMINTICS | SMITHKLINE CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |