Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.93 |
| ▸ | HTR1A | P08908 | 3/20 | 0.93 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.93 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.93 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.93 |
| ▸ | HTR2A | P28223 | 3/20 | 0.93 |
| ▸ | HRH1 | P35367 | 3/20 | 0.93 |
| ▸ | DRD3 | P35462 | 3/20 | 0.93 |
| ▸ | DRD4 | P21917 | 2/20 | 0.93 |
| ▸ | HTR2C | P28335 | 2/20 | 0.93 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.93 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.93 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.93 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.93 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.93 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Haloperidol SCHEMBL5070670 | 0.97 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| SCHEMBL20254453 | 0.97 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL8264 | 0.97 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL15545886 | 0.95 | DRD2 (0.98) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL317367 | 0.95 | DRD2 (0.98) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL28699132 | 0.94 | DRD2 (0.96) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL8741248 | 0.93 | DRD2 (0.94) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL20644145 | 0.92 | DRD2 (0.92) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL9507217 | 0.92 | DRD2 (0.92) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| SCHEMBL9051774 | 0.92 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4065565-A | Acylhydrazones and anti-psychotic compositions thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-12-27 | — | — | US | disclosed |