Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Haloperidol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 14/20 | 0.98 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.98 |
| ▸ | DRD3 known ✓ | P35462 | 3/20 | 0.98 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.98 |
| ▸ | HTR1A | P08908 | 3/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.98 |
| ▸ | HRH1 | P35367 | 3/20 | 0.98 |
| ▸ | HTR2C | P28335 | 2/20 | 0.98 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Haloperidol SCHEMBL28699132 | 0.99 | DRD2 (0.96) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL8264 | 0.99 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL5070670 | 0.99 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| SCHEMBL20254453 | 0.99 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL317367 | 0.98 | DRD2 (0.98) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL8741248 | 0.96 | DRD2 (0.94) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| SCHEMBL11752117 | 0.95 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL20644145 | 0.95 | DRD2 (0.92) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Haloperidol SCHEMBL9507217 | 0.95 | DRD2 (0.92) | DRD2ADRA1AHTR1AADRA2AADRA2B | |
| Chlorohaloperidol SCHEMBL4112719 | 0.93 | DRD2 (1.00) | DRD2ADRA1AHTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107880988-B | Environment-friendly forming oil for stainless steel and preparation method thereof | 广州市联诺化工科技有限公司 | 2021-02-09 | — | — | CN | claimed |
| CN-107880988-B | Environment-friendly forming oil for stainless steel and preparation method thereof | 广州市联诺化工科技有限公司 | 2021-02-09 | — | — | CN | disclosed |
| CN-107815344-B | Environment-friendly semisynthetic cutting fluid and preparation method thereof | 广州市联诺化工科技有限公司 | 2020-08-25 | — | — | CN | disclosed |
| US-10314795-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180235910-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine | 2018-08-23 | — | — | US | disclosed |
| US-9889102-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine | 2016-12-15 | — | — | US | disclosed |
| US-9388126-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | DREXEL UNIVERSITY (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150166472-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | DREXEL UNIVERSITY | 2015-06-18 | — | — | US | disclosed |
| EP-2874997-A2 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Drexel University (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014015157-A2 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2014-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166472-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | DRD2 1233/4885HTR2A 279/4885DRD3 1407/4885 |
| US-10314795-B2 | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same | SIGMAR1, TMEM97, ADRM1 | DRD2 1257/4885HTR2A 242/4885DRD3 1534/4885 |
| US-20180235910-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | DRD2 1343/4885HTR2A 301/4885DRD3 1505/4885 |
| US-20160361279-A1 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | TMEM97, SIGMAR1, ADRM1 | DRD2 1343/4885HTR2A 301/4885DRD3 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.