Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.35 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.35 |
| ▸ | PPP5C | P53041 | 1/20 | 0.35 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.35 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13678802 | 1.00 | TP53 (0.35) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL12110769 | 0.74 | TP53 (0.38) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL910568 | 0.72 | TP53 (0.50) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL911568 | 0.72 | TP53 (0.50) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL16923817 | 0.72 | TP53 (0.39) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL23634039 | 0.72 | TP53 (0.39) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL10017614 | 0.72 | TP53 (0.39) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL23979209 | 0.70 | MEN1 (0.32) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL12359380 | 0.70 | TP53 (0.35) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL13515256 | 0.68 | TP53 (0.33) | TP53CYP3A4MAPK1HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695149-B2 | 1,2,6-substituted benzimidazoles as flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-07-04 | — | — | US | disclosed |
| US-20160039790-A1 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-11 | — | — | US | disclosed |
| US-9089569-B2 | 1,2,6-substituted benzimidazoles as flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-28 | — | — | US | disclosed |
| US-20150119382-A1 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-30 | — | — | US | disclosed |
| US-8952177-B2 | 1,2,6-substituted benzimidazoles as FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-10 | — | — | US | disclosed |
| US-20140275029-A1 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-18 | — | — | US | disclosed |
| US-4009278-A | Antimicrobial composition and method containing N-(3,5-dihalophenyl)-imide compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039790-A1 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS | FEN1, FOXM1, F12 | TP53 476/4885CYP3A4 9/4885MAPK1 4083/4885 |
| US-20140275029-A1 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS | FEN1, FOXM1, F12 | TP53 476/4885CYP3A4 9/4885MAPK1 4083/4885 |
| US-20150119382-A1 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS | FEN1, FOXM1, F12 | TP53 476/4885CYP3A4 9/4885MAPK1 4083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.