Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.31 |
| ▸ | PPP5C | P53041 | 1/20 | 0.31 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30875753 | 0.72 | — | — | |
| SCHEMBL30875722 | 0.72 | POLB (0.36) | TSHR | |
| SCHEMBL11758596 | 0.70 | TP53 (0.35) | MEN1KMT2ATP53CYP3A4MAPK1 | |
| SCHEMBL13678802 | 0.70 | TP53 (0.35) | MEN1KMT2ATP53CYP3A4MAPK1 | |
| SCHEMBL12110769 | 0.68 | TP53 (0.38) | MEN1KMT2ATP53CYP3A4MAPK1 | |
| SCHEMBL4328440 | 0.67 | HTT (0.30) | HTT | |
| SCHEMBL911568 | 0.66 | TP53 (0.50) | MEN1KMT2ATP53CYP3A4MAPK1 | |
| SCHEMBL10017614 | 0.66 | TP53 (0.39) | MEN1KMT2ATP53CYP3A4MAPK1 | |
| SCHEMBL16923817 | 0.66 | TP53 (0.39) | MEN1KMT2ATP53CYP3A4MAPK1 | |
| SCHEMBL23634039 | 0.66 | TP53 (0.39) | MEN1KMT2ATP53CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113149968-B | Compound serving as ketohexokinase inhibitor and application thereof | 博济医药科技股份有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-114181198-A | Pyrimidine derivative ketohexokinase inhibitor and application thereof | 山东轩竹医药科技有限公司 | 2022-03-15 | — | — | CN | disclosed |
| WO-2021217734-A1 | FUSED RING COMPOUND USED AS KETOHEXOKINASE INHIBITOR | 广州博济医药生物技术股份有限公司 | 2021-11-04 | — | — | WO | disclosed |