Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 16/20 | 0.41 |
| ▸ | EEF2K | O00418 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 3/20 | 0.39 |
| ▸ | EPHA3 | P29320 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409644 | 0.88 | MEN1 (0.36) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1176228 | 0.86 | IKBKB (0.57) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL3088342 | 0.80 | ALDH1A1 (0.51) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1176342 | 0.77 | LIMK1 (0.60) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1175976 | 0.77 | LIMK1 (0.55) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1176201 | 0.76 | LIMK1 (0.50) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL3410251 | 0.75 | IKBKB (0.41) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1176017 | 0.74 | LIMK1 (0.60) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1176092 | 0.74 | HPGD (0.56) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1176597 | 0.74 | LIMK1 (0.59) | MEN1ALDH1A1GAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015724-A | Thienopyrimidines | MERCK PATENT GMBH | 2011-04-13 | — | — | CN | claimed |
| US-20110028472-A1 | THIENOPYRIMIDINES | MERCK PATENT CESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-02-03 | — | — | US | claimed |
| CN-102015724-A | Thienopyrimidines | MERCK PATENT GMBH | 2011-04-13 | — | — | CN | disclosed |
| US-20110028472-A1 | THIENOPYRIMIDINES | MERCK PATENT CESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-02-03 | — | — | US | disclosed |
| US-20110028472-A1 | THIENOPYRIMIDINES | MERCK PATENT CESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-02-03 | — | — | US | disclosed |
| US-20110028472-A1 | THIENOPYRIMIDINES | MERCK PATENT CESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028472-A1 | THIENOPYRIMIDINES | TGFBR1, TYMP, TGFBR2 | MEN1 2849/4885ALDH1A1 690/4885GAA 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.