Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11760500 | 0.92 | AMY1A (0.38) | AMY1APPARGKDM4EPOLBMAPT | |
| SCHEMBL11765128 | 0.92 | PPARG (0.37) | PPARGKDM4EPOLBMAPTRECQL | |
| SCHEMBL11765459 | 0.87 | PPARG (0.47) | PPARGKDM4EMAPTNPSR1TDP1 | |
| SCHEMBL11764094 | 0.86 | MAPT (0.36) | AMY1APPARGKDM4EPOLBMAPT | |
| SCHEMBL11763054 | 0.85 | PSEN1 (0.42) | PPARGKDM4EMAPTMDM2RXRA | |
| SCHEMBL11767110 | 0.84 | PPARG (0.50) | PPARGKDM4EMAPTNPSR1TDP1 | |
| SCHEMBL11765291 | 0.84 | MAPT (0.39) | AMY1APPARGKDM4EPOLBMAPT | |
| SCHEMBL11763704 | 0.84 | RXRA (0.47) | PPARGMAPTTDP1RXRAPSEN1 | |
| SCHEMBL11764221 | 0.83 | LRRK2 (0.33) | PPARGMAPTNPSR1TDP1RXRA | |
| SCHEMBL11765230 | 0.82 | LCK (0.40) | PPARGMAPTRXRALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4061771-A | Ethynylindenyl compounds and derivatives thereof used in the treatment of pain, fever and inflammation | WILLIAM H. RORER, INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-3983253-A | Ethynylindenyl compounds and derivatives thereof used in the treatment of pain, fever and inflammation | WILLIAM H. RORER, INC. (US) | 1976-09-28 | — | — | US | disclosed |