Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076454 | 0.87 | — | — | |
| Sulfurous Acid SCHEMBL11769240 | 0.84 | CPA1 (0.31) | CPA1 | |
| SCHEMBL587037 | 0.74 | — | — | |
| Bicarbonate SCHEMBL11768566 | 0.74 | GRIK1 (0.32) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL667528 | 0.71 | GRIK1 (0.37) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL19745183 | 0.70 | GRIK1 (0.30) | GRIK1GRIK2 | |
| SCHEMBL28596838 | 0.70 | GRIK1 (0.32) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL4148404 | 0.70 | CTSC (0.35) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL174504 | 0.70 | GRIK1 (0.32) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL7002068 | 0.69 | CYP2D6 (0.42) | GRIK1GRIK2CYP2C19ABCC4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3979401-A | Polyfunctional aliphatic and cycloaliphatic cyclic nitrile sulfites and carbonates | ATLANTIC RICHFIELD COMPANY (US) | 1976-09-07 | — | — | US | disclosed |