Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.34 |
| ▸ | KDM4A | O75164 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677966 | 0.91 | ABCC4 (0.47) | CYP2D6NFKB1SLC6A2SLC6A4BLM | |
| SCHEMBL5682272 | 0.83 | MAPT (0.42) | CYP2D6NFKB1SLC6A2SLC6A4BLM | |
| SCHEMBL29069484 | 0.81 | TET2 (0.44) | CYP2D6NFKB1SLC6A2SLC6A4BLM | |
| SCHEMBL29011276 | 0.75 | FOLH1 (0.46) | CYP2D6NFKB1MAPTTET2KDM4A | |
| SCHEMBL29011277 | 0.75 | FOLH1 (0.46) | CYP2D6NFKB1MAPTTET2KDM4A | |
| Bicarbonate SCHEMBL11768566 | 0.74 | GRIK1 (0.32) | CYP2C19GRIK1GRIK2 | |
| SCHEMBL7043004 | 0.74 | TET2 (0.38) | CYP2D6NFKB1SLC6A2SLC6A4BLM | |
| Nitrous Acid SCHEMBL29026025 | 0.74 | TET2 (0.38) | CYP2D6NFKB1SLC6A2SLC6A4BLM | |
| SCHEMBL6356171 | 0.74 | GABRP (0.41) | CYP2D6NFKB1TSHRMAPTTET2 | |
| SCHEMBL27996826 | 0.74 | TET2 (0.38) | CYP2D6NFKB1SLC6A2SLC6A4BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040171876-A1 | Processes for the production of alpha-difluoromethyl ornithine (DFMO) | BRISTOL-MYERS SQUIBB COMPANY | 2004-09-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171876-A1 | Processes for the production of alpha-difluoromethyl ornithine (DFMO) | ODC1, OTC, OAT | CYP2D6 579/4885NFKB1 1877/4885SLC6A2 3871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.