Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744433 | 0.80 | TSHR (0.52) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL11230508 | 0.77 | TSHR (0.49) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL10956733 | 0.77 | KMT2A (0.49) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL11219161 | 0.77 | TSHR (0.49) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL28709509 | 0.76 | CPA1 (0.47) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL1606582 | 0.76 | TSHR (0.65) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9537072 | 0.75 | TSHR (0.46) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL11268069 | 0.75 | TSHR (0.46) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL11274649 | 0.75 | KMO (0.49) | TSHRKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL29110672 | 0.74 | MEN1 (0.58) | KMT2AMAPTMEN1CES1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011321-A | 6-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXYARYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-03-08 | — | — | US | disclosed |