Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 5/20 | 0.37 |
| ▸ | CES2 | O00748 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28539171 | 0.67 | TDP1 (0.48) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL29767713 | 0.66 | TDP1 (0.46) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL8766967 | 0.64 | LMNA (0.43) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL7803273 | 0.63 | CES1 (0.37) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL64920 | 0.63 | AKR1C1 (0.44) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL1694005 | 0.63 | ALDH1A1 (0.46) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL2417682 | 0.60 | CES1 (0.48) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL8463882 | 0.60 | CES1 (0.48) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| SCHEMBL11341980 | 0.59 | CES1 (0.46) | MAPTTDP1TSHRCYP3A4CYP2C19 | |
| Benzophenone SCHEMBL1695422 | 0.58 | ALDH1A1 (0.88) | MAPTTDP1TSHRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4059584-A | ANTIINFLAMMATORY | PFIZER (US) | 1977-11-22 | — | — | US | disclosed |
| US-4002623-A | Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines | PFIZER INC. (US) | 1977-01-11 | — | — | US | disclosed |